Absorption of Oligodeoxynucleotide by Suppository from Rat Rectal Route.
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چکیده
منابع مشابه
Formulation and Evaluation of Irinotecan Suppository for Rectal Administration
Irinotecan suppository was prepared using the moulding method with a homogeneous blend. A sensitive and specific fluorescence method was developed and validated for the determination of irinotecan in plasma using HPLC. The pharmacokinetics of intravenous administered and rectal administered in rabbits was investigated. Following a single intravenous dose of irinotecan (50 mg/kg), the plasma iri...
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OBJECTIVE To determine the frequency of perineal pain after childbirth after a single dose of diclofenac rectal suppository. METHODS This cross-sectional study was conducted at Shaikh Zayed Women Hospital, Larkana, Pakistan, from April to September 2014, and comprised patients who were admitted to the labour room for normal vaginal delivery. A single dose of rectal diclofenac suppository of 1...
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To achieve successful delivery of drug locally as well as systematically rectal route has proved its potential. The main objective of this research work was to evaluate the in vivo performance of paracetamol Suppocire CP suppository. Initially, suppositories were prepared, evaluated for their physicochemical parameters and in vitro drug release. An in vivo investigation of paracetamol availabil...
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EDITORIAL The penetration of drugs in the eye after topical administration is one of the most interesting challenges the pharmaceutical science is facing. The objective of the scientist is to penetrate the protective barriers of the eye without damaging ocular structures. In contrast with other epithelia, the epithelium of the ocular surface is not prepared for absorption which means that the t...
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The absorption of diazepam after rectal administration was studied in children with epilepsy. When given as a solution, diazepam was rapidly absorbed and produced serum diazepam concentrations above 200 ng/ml within 10 minutes in most children. However, a commercial suppository formulation was absorbed slowly and cannot be recommended for urgent treatment of fits. There is a need in the UK for ...
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ژورنال
عنوان ژورنال: Biological and Pharmaceutical Bulletin
سال: 1997
ISSN: 0918-6158,1347-5215
DOI: 10.1248/bpb.20.1116